Garcinia Cambogia or Garcinia Indica is a fruit that has been consumed safely for hundreds of years by locals of all ages in the Indian sub-continent for general health, lipid management and, weight management. The fruit has been used in culinary, as a food-supplement, and as an Ayurvedic medicine. The benefits of Garcinia fruit were introduced to the western world in the form of dietary food supplement several years ago. Since than several scientific studies have been conducted to test the mechanism of actions, safety, tolerability and, efficacy of the fruit extract. The standardized extract of Garcinia fruit has hydroxycitric acid (HCA) as major constituent. HCA is a derivative of citric acid and can also be found in other species as Garcinia atroviridis.
The active ingredient in the fruit's rind, hydroxycitric acid, or HCA, has boosted fat-burning and cut back appetite in studies. It appears to block an enzyme called citrate lyase, which your body uses to make fat. Several scientific studies have suggested various mechanisms for Garcinia activity, including inhibition of energy metabolism and appetite suppression increased release of serotonin (which makes you feel less hungry), direct action on adipocytes causing lipid droplet dispersion, reduce oxidative stress, and altering transcription. For more information please read the studies below.
There were several clinical trials conducted to test the efficacy of Garcinia (or HCA) towards obesity. However, these clinical trials have been vastly heterogeneous. In other words, the trials often included small number of subjects, different doses of HCA, different treatment periods, and measured different anthropomorphic parameters. For example, in the study by Preuss et al 60 moderately obese subjects (ages 21-50, BMI >26 kg/m2) were given 4.6g HCA for 8 weeks 30-60 min before meals. A statistically significant reduction in appetite (effect size: 2.79), BMI (decreased by 5-6%) and, body weight (decreased by 1.5-2.5kg) following supplementation of HCA was observed in comparison to the placebo. In another study obese women (BMI >25) received 2.4g (800mg 3X/day) of Garcinia extract (50% of HCA) or placebo for 60 days. In this study, Weight, BMI, waist-hip ratio and percentage of fat mass, did not show statistically significant difference among the treatment and the placebo group, but triglycerides (TG) was significantly reduced in the treated group (p=0.0002). Yet, in another randomized, double-blind, placebo-controlled trial 2g/day of Garcinia for 10 weeks did not show a significant differences in body weight, body mass index (BMI) and waist-to-hip ratio (WHR) compared to placebo but there was a statistically significant change in %body fat and internal fat (p < 0.05). Notice the difference in the dosage of HCA and treatment periods in these studies that precludes the direct comparison of the studies.
There are meta-analyses on all the randomized clinical trials conducted on the efficacy of Garcinia or HCA to conclude whether it is efficacious or not. One such Meta-analysis (including 12 randomized clinical trials with a total of 706 participants) reveals a statistically significant difference in body weight between the HCA and placebo groups. The average effect size was, however, small (-0.88 kg; 95% CI), with a P value of .05. This translates to about 1% in body weight loss in HCA group compared with placebo, but the clinical relevance still remains to be established.
Clinical trials mentioned above may not show dramatic results that modern allopathic medicine (such as phsychostimulants or Orlistat) may show. However, such modern medicine come with the range of adverse effects as well. In contrast adverse events reported in the Garcinia or HCA trials are none to minor as headache, skin rash, or gastrointestinal (GI) symptoms.
While some information can be taken from these short-term heterogeneous trials, a firm conclusion cannot be reached. In contrast the continuous use by the natives in Indian-subcontinent must have shown results to encourage them to use it even today. For further information we recommend following readings;
H. G. Preuss, D. Bagchi, M. Bagchi, C. V. S. Rao, D. K. Dey, and S. Satyanarayana; Effects of a natural extract of (-)-hydroxycitric acid (HCA-SX) and a combination of HCA-SX plus niacin-bound chromium and Gymnema sylvestre extract on weight loss . Diabetes, Obesity and Metabolism, 6, 2004, 171-180.
Igho Onakpoya, Shao Kang Hung, Rachel Perry, BarbaraWider, and Edzard Ernst; The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review andMeta-Analysis of Randomised Clinical Trials. Journal of Obesity Volume 2011, 1-9.
Carlos A. R. Vasques, Ricardo Schneider, Luiz C. Klein-Junior, Andressa Falavigna, Ivone Piazza and Simone Rossetto; Hypolipemic Effect of Garcinia cambogia in Obese Women . Phytother. Res., 2014, 28: 887-891.
Steven B. Heymsfield, David B. Allison, Joseph R. Vasselli, Angelo Pietrobelli, Debra Greenfield, Christopher Nunez; Garcinia cambogia (Hydroxycitric Acid) as a Potential Antiobesity Agent A Randomized Controlled Trial. JAMA. 1998;280(18):1596-1600.
Inconnate Garcinia Cambogia is produced in a Food and Drug Administration (FDA) registered facility, and that is also certified Good Manufacturing Practices (cGMP). Our strict standard offers you to get a safe, quality product at a affordable price. According to some studies it is recommended that you speak with your doctor before taking Garcinia if you are taking a statins for cholesterol or if you are diabetic. We also do not recommend anyone with Alzheimer's, dementia, pregnant, may become pregnant or breast feeding to take Garcinia supplement.
If Garcinia is taken as directed there should be no side effects, however, no product can realistically claim no side effects. It is to note that the dietary supplements are to be used as supplements and are not intended to "cure"/"mitigate" obesity in short period of time. Therefore, we encourage you to use your own judgment and use dietary supplement as needed. Taking more of the product than recommended may be linked to nausea, digestive tract discomfort, diarrhea, and headache.
Quality and true Herbal supplement is our mission and thus the attributes of our products that set us apart from another manufacturer are;
The recommended dose for Garcinia is 500 mg (1 capsule twice a day at least 30 minutes before a meal) taking more than recommended may cause adverse effects.
There have been no reports of interactions; however, we do not recommend pregnant or nursing women to take Garcinia.
Although there are no direct reports but if you are taking a statin or are diabetic, you should avoid taking Garcinia without speaking with your doctor. We do not recommend anyone with Alzheimer's or dementia either.
No studies have not suggested that.
No, our product is caffeine free.
According to the studies Garcinia can only target fat in general, not a specific location.
Not when following our recommended dosage. Garcinia is known to cause nausea when taking more than 3,000 mg per day. If you notice nausea, reduce your dosage.
Yes, according to studies Garcinia is known to suppress appetite.
No. During pregnancy supplement directed at causing weight loss should be avoided anyway. While there are no studies that show that Garcinia would be harmful during pregnancy, we would rather have you be cautious and stop all supplements except for those your doctor suggests you take.