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O-Loss Fat Burner

Quality Attributes

Product Description

  • Item #: IN-115
  • Availability: In Stock
  • Bottle Size: 60, 90, 120, 180 capsules per bottle
  • Recommended Serving: 3 capsule per day
  • Maximum Serving: 3 capsules per day
  • Dosage per day: 3000 mg Garcinia, 1350mg Guggul, and 450mg Forskohlii

QUESTION AND ANSWERS

Q: What is Inconnate Healthcare’s “O-LOSS” Super Fat Burner-

"O-LOSS" Super Fat Burner is a special Inconnate formula that consist three Ayurvedic herbs; Garcinia Indica, Guggul (Commiphora mukul), and Coleus Forskohlii. The fruits of Garcinia, the roots of Forskohlii, and the resin extract of Guggul, have been historically used in Ayurveda not only to improve weight management and fat metabolism but also healthy heart, blood pressure, and other cardiovascular diseases associated with cholesterol and obesity. For hundreds of years Garcinia, Forskohlii, and Guggul have also been safely used by people of all ages, in culinary and as food supplement, in the Indian sub-continent. The benefits of these herbs were recognized by the western world several years ago and since then numerous research studies were conducted to understand the way these herbs work. These herbs are now popularly used all over the world for weight management and fat burning purposes.

Q: Is "O-LOSS" Better than prescription allopathic medications?

Clinical trials may not show dramatic results that modern allopathic medicine (such as phsychostimulants or Orlistat) may show. However, such modern medicines come with the range of adverse effects as well such as stimulatory effects of phsycostimulants. In contrast adverse events reported in the Garcinia, forskolin or guggul trials are none to minor as headache, skin rash, or gastrointestinal (GI) symptoms.

Q: How is “O-LOSS” Supplement by Inconnate different from others

As mentioned earlier O-Loss is a special blend of three herbs known to support weight management and healthy BMI. Our blend is so far very well received and is registered with the in Kuwait and India. O-Loss is produced in a Food and Drug Administration (FDA) registered facility, and that is also certified Good Manufacturing Practices (cGMP). Our strict standard offers you to get a safe, quality product at a affordable price.

Q: Are there any Side effects?

If “O-LOSS” is taken as directed there should be no side effects. It is to note that the dietary supplements are to be used as supplements and are not intended to "cure"/"mitigate" obesity in short period of time. Therefore, we encourage you to use your own judgment and use dietary supplement as needed.

Q: How many capsules should you take?

The recommended dose for “O-Loss” is 3 capsule a day at least 30 minutes before a meal. taking more than recommended may cause adverse effects.

Q: Does it affect birth control, hormones or your period?

There have been no reports of interactions of any of the ingredients in O-Loss; however, we do not recommend pregnant or nursing women to take O-Loss.

Q: Does O-Loss have interactions with other drugs?

Although there are no direct reports but if you are taking a statin or are diabetic, you should avoid taking O-Loss without speaking with your doctor. We do not recommend anyone with abnormal heart beats (arrhythmia), Alzheimer's or dementia either. Capsule of O-Loss should not be taken by women who are pregnant or planning to be pregnant.

Q: Can O-Loss raise blood pressure or blood sugar?

No studies have not suggested.

Q: Does it have caffeine?

No, our product is caffeine free.

Q: Will O-Loss get rid of cellulite or help reduce fat in the buttocks?

According to the studies neither Garcinia, forskolin, nor guggul in O-Loss can target a specific location. Overall these herbs just target the overall fat of the body.

Q: Does O-Loss cause nausea?

We have not received any complaints of nausea when following our recommended dosage.

Q: Can I take it if I am pregnant or if I am thinking of getting pregnant?

No. During pregnancy supplement directed at causing weight loss should be avoided anyway.

Q: Can I take it while breastfeeding?

NO, we do not suggest that.

Q: What is the Mechanism of action of ingredients in “O-LOSS” Super Fat Burner -

The active ingredient in the Garcinia fruit rind is hydroxycitric acid, or HCA. The active ingredient in Forskohlii root is forskolin, and Guggul resin extract contains Guggulsterone. While more in-depth research is needed to fully understand the biochemistry behind the benefits of these herbs, several studies suggested the following mechanisms.

Hydrocitric acid in Garcinia appears to block an enzyme called ATP-citrate lyase, ATP-citrate lyase is a cytosolic enzyme that catalyses the cleavage of citrate into oxaloacetate and acetyl-CoA which is then used to make fat in body. By inhibiting citrate lyase HCA inhibits the endogenous lipogenic activity thus reducing the fat build up. In animal studies it is also observed that Garcinia extract may increase leptin and insulin sensitivity in animals, and thus inducing satiety and reducing hunger. Therefore, Garcinia may not only decreases the fat build-up in the body but also increases the satiety.

Coleus Forskohlii’s forskolin is an activator of an enzyme called adenyl cyclase (AC) that participates in mechanisms for metabolism of fat in the body. Adenyl cyclase aids in accumulation of Cyclic Adenosine Monophosphate, or Cyclic AMP (cAMP) in body cells. Cyclic AMP promotes the breakdown of stored fats in animal and human fat cells, regulates the body’s thermogenic response to food, increases the body’s basal metabolic rate, and increases utilization of body fat. It may also release fatty acids from adipose tissue, loss of body fat, and theoretically improve lean body mass.

Guggulsterone in Guggul acts as a modulator of several nuclear receptors as FXR, AR, MR, ER GR etc. In the liver cells Guggulsteron modulates the activity of FXR and therefore increases the expression of the proteins critical in synthesis of bile acid from cholesterol in the liver and in transporting the bile acid across the liver membrane. By their action on the nuclear receptors Guggulsteron increase the expression of proteins that in-turn increase the synthesis of bile acid by utilizing the cholesterol in the body. Therefore, the cholesterol from the body is utilized. The bile acid formed in this process needs to be excreted out of the body because bile acid in a negative feedback inhibitor of the FXR. Guggulsteron has also been shown to increase the expression of bile acid transporter proteins that enhance the bile acid transport across the membrane and thus enhance the overall release of bile acid from the body.

Therefore, combining all three herbs in “O-LOSS” Super fate Burner formula, in principle, a decreased production of fat, decreased production of cholesterol by liver, and increased metabolism of fat and cholesterol, is expected. Thus, “O-LOSS” formula might reduce the overall fat and cholesterol of the body.

Q: Scientific studies that have tested Forskolin, Garcinia, and Guggul for obesity –

There were several clinical trials conducted to test the efficacy of Garcinia (or HCA), Forskohlii (or forkolin), and Guggul resine extract towards obesity. Although, these clinical trials have been vastly heterogeneous and for short duration of time, overall the studies do suggest benefits of these three herbs towards obesity and fat metabolism in men and women.

Studies on Garcinia - There were several clinical trials conducted to test the efficacy of Garcinia (or HCA) towards obesity. However, these clinical trials have been vastly heterogeneous. In other words, the trials often included small number of subjects, different doses of HCA, different treatment periods, and measured different anthropomorphic parameters. For example, in the study by Preuss et al 60 moderately obese subjects (ages 21-50, BMI >26 kg/m2) were given 4.6g HCA for 8 weeks 30-60 min before meals. A statistically significant reduction in appetite (effect size: 2.79), BMI (decreased by 5-6%) and, body weight (decreased by 1.5-2.5kg) following supplementation of HCA was observed in comparison to the placebo. In another study obese women (BMI >25) received 2.4g (800mg 3X/day) of Garcinia extract (50% of HCA) or placebo for 60 days. In this study, Weight, BMI, waist-hip ratio and percentage of fat mass, did not show statistically significant difference among the treatment and the placebo group, but triglycerides (TG) was significantly reduced in the treated group (p=0.0002). Yet in another randomized, double-blind, placebo-controlled trial 2g/day of Garcinia for 10 weeks did not show a significant differences in body weight, body mass index (BMI) and waist-to-hip ratio (WHR) compared to placebo but there was a statistically significant change in %body fat and internal fat (p < 0.05). Notice the difference in the dosage of HCA and treatment periods in these studies that precludes the direct comparison of the studies.

There are meta-analyses on all the randomized clinical trials conducted on the efficacy of Garcinia or HCA to conclude whether it is efficacious or not. One such Meta-analysis (including 12 randomized clinical trials with a total of 706 participants) reveals a statistically significant difference in body weight between the HCA and placebo groups. The average effect size was, however, small (-0.88 kg; 95% CI), with a P value of .05. This translates to about 1% in body weight loss in HCA group compared with placebo, but the clinical relevance still remains to be established.

Studies on Forskolin - Recently, Forskohlii was investigated for its weight loss effects in mildly over weight women in a double blind and randomized manner, 23 females (250 mg of 10% Forskolin (n=7) or a placebo (n=12) two times per day for 12-wks. While no significant differences were observed in caloric intake the treatment with Forskohlii tended to mitigate gains in body mass within 12 weeks only. The subjects also reported less fatigue, hunger, and fullness. Similarly in a randomized, double-blind, placebo-controlled study for 12 weeks in obese men (BMI>26 kg/m2; treatment, n =15; placebo, n =15) Forskolin (250mg Forskohlii; 10% Forskolin) decreased body fat percentage and fat mass compared with the placebo group. Additionally, serum free testosterone levels were significantly increased in the forskolin group compared with the placebo group.

Studies of Guggul – Several clinical trials have been conducted to test the effect of Guggul on serum total cholesterol, LDL, HDL and total adipose build. A randomized controlled double-blind trail was conducted in 1978 with total of 120 patients with hyperlipidemia. Gum guggul at 2 g twice daily or an extract at 500 mg three times daily for 21 days significantly reduced the serum lipid levels in hyperlipidemic non-obese patients. These beneficial effects were not observed in hyperlipidemic obese subjects. Similar results were obtained from at least 3-4 other studies conducted with similar dosage in non-obese and obese hyperlipidemic subjects. One of larger such studies (total of 233 subjects) was conducted to compare gugulipid (125 subjects) with an antihyperlipidemic drug clofibrate (108 subjects). At the end of the study, gugulipid significantly decreased total serum cholesterol by 11% and triglycerides by 17%, comparable to those of clofibrate (10% and 22%, respectively). Along with these lipolytic affects in a placebo-controlled trial of 70 obese subjects, Patwardhan et al. showed significant weight loss and decrease in body measurements, as well with an Ayurvedic guggul formulations.

In another smaller study, patients (women) were given standard doses of the guggul formulations. A weight loss of 1 to 3 kg was observed in four patients within 1 to 2.5 months, while seven patients who showed a 4- to 6.5-kg weight loss and received the formulations for 3.5 to 6 months. Significant weight loss (4 to 5 kg) occurred in two patients within a month and surprisingly within 1 week in a single subject. It is interesting to note that only two women showed no change, despite the fact that one was given the formulations for 4 months. The experiential data suggest the need to increase the dose, as per the individual needs of the patient, and concurrently advise essential diet and exercise measures. However, some patients who are given higher doses may complain of gastrointestinal irritation and burning.

While some information can be taken from these short-term heterogeneous trials, a firm conclusion cannot be reached. In contrast the continuous use by the natives in Indian-subcontinent must have shown results to encourage them to use it even today.

List of Studies

Igho Onakpoya, Shao Kang Hung, Rachel Perry, BarbaraWider, and Edzard Ernst; The Use of Garcinia Extract (Hydroxycitric Acid) as a Weight loss Supplement: A Systematic Review andMeta-Analysis of Randomised Clinical Trials. Journal of Obesity Volume 2011, 1-9.

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Shonteh Henderson, Bahrat Magu, Chris Rasmussen, Stacey Lancaster, Chad Kerksick, Penny Smith, Charlie Melton, Patty Cowan, Mike Greenwood, Conrad Earnest, Anthony Almada, Pervis Milnor, Terri Magrans, Rodney Bowden, Song Ounpraseuth, Ashli Thomas, & Richard B. Kreider; Effects of Coleus Forskohlii Supplementation on Body Composition and Hematological Profiles in Mildly Overweight Women. Journal of the International Society of Sports Nutrition. 2(2): 54-62, 2005.

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Kuppurajan K, Rajagopalan SS, Rao TK, Sitaraman R.. Effect of guggulu (Commiphora mukul--Engl.) on serum lipids in obese, hypercholesterolemic and hyperlipemic cases. J Assoc Physicians India. 1978 May;26(5):367-73.

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Thomas P. Burris, Chahrzad Montrose, Keith A. Houck, Harold E. Osborne, Wayne P. Bocchinfuso, Benjamin C. Yaden, Christine C. Cheng, Richard W. Zink, Robert J. Barr, Christoper D. Hepler, Venkatesh Krishnan, Heather A. Bullock, Lorri L. Burris, Rachelle J. Galvin, Kelli Bramlett, and Keith R. Stayrook. The Hypolipidemic Natural Product Guggulsterone Is a Promiscuous Steroid Receptor Ligand. Mol Pharmacol 67:948–954, 2005.

Nityanand, S. and Kapoor, N.K., Hypocholesterolemic effect commiphora mukul resin (guggul), Ind. J. Exp. Biol., 9, 376, 1971.

Paranjpe, P., Patki, P., and Patwardhan, P., Ayurvedic treatment of obesity: a randomized double blind, placebo-controlled clinical trial, J. Ethnopharmacol., 29, 1–11, 1990.